T1 measurements differ depending on magnetic field strength and MRI scanner manufacturer.
- LiverMultiScan cT1 measurements are corrected for MR field strength and standardized over different MRI vendors so that the metrics are consistent across different MRI systems.
- Repeatability and reproducibility of cT1 has been shown to have high precision (defined as the agreement between repeated cT1 measurements) across different field strengths, scanner manufacturers, and models.11
cT1 measurements have been corrected for the presence of iron in the liver, which impacts the MRI signal and without correction may lead to an incorrect estimation of fibro-inflammation.
cT1 and T1 measurements can be influenced by increasing fat content and this is dependent on MRI scanner, scanning parameters, and field strength.12 Fat, fibrosis, and inflammation are all hallmarks of liver disease, so an increase in cT1 as a result of increased levels of fibro-inflammation and liver fat, may all contribute to the sensitivity of cT1 as a prognostic indicator.
Perspectum has invested heavily in the standardization of LiverMultiScan PDFF across magnetic field strengths, scanner manufacturers, and models to provide a robust measure of liver fat.16,17
This compares favorably with the results of a meta-analysis of MRI-PDFF from 28 studies led by the Quantitative Imaging Biomarkers Alliance (QIBA), revealing excellent repeatability and reproducibility.18