Intervene Early, While Liver Disease is Still Reversible

Treatments exist today that enable patients to manage and even reverse liver disease. Lifestyle adjustments and some additional approaches have been employed successfully. LiverMultiScan is the first reliable noninvasive procedure that offers a comprehensive view of liver health and allows monitoring of the effectiveness of treatment.

  • Patient-friendly reports
  • Heterogeneous liver tissue and regional variation
  • Reports received in as little as 2 hours
  • Reports delivered through a seamless cloud-based service

Key Features

Accurate

Accurate and robust quantitative metrics shown to correlate with biopsy1, 2, 3, 4

Patient Focused

Suitable as part of the diagnostic pathway for patients and for clinical trials

Standardized

Standardized across all major MRI manufacturers and field strengths6

Fast

Quick, contrast-free scan

Prognostic

cT1 predicts clinical outcomes5

Repeatable

cT1 has 'best-in-class' repeatability

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Three metrics in one single scan

cT1

PDFF

T2*

Understanding cT1

Both fibrosis and inflammation processes cause an increase in tissue water content. Higher cT1 values are observed as tissue water content increases. cT1 has been correlated with fibro-inflammatory disease activity on histology6,7,8,1–3,5 and clinical outcomes.9,10

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How cT1 may appear on a report

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LiverMultiScan cT1 accurately identified NASH patients at high risk of disease progression3,5

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cT1 as a prognostic biomarker: cT1 has been shown to predict clinical outcomes in chronic liver disease (9,10)

Understanding MRI-PDFF

MRI proton density fat fraction (PDFF) is a measurement of the ratio of density of mobile protons from fat to the total density of mobile protons from fat and water. It is a fundamental MRI property of tissue and reflects the concentration of fat within the tissue.13

 

A leader in MRI-PDFF using LMS IDEAL

LiverMultiScan uses LMS IDEAL for liver fat measurement, which is based on a well-established MRI-PDFF technique known as IDEAL (iterative decomposition of water and fat with echo asymmetry and least squares estimation).13 The IDEAL technique addresses the impact on the MRI signal of iron in the liver and the multi-spectral nature of liver fat.14

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How PDFF may appear on a report

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LiverMultiScan PDFF as as a diagnostic tool for NASH

Understanding T2*

T2* is a time constant (measured in milliseconds) describing the decay of an MRI signal. This decay is influenced by spatial variation (inhomogeneities) in the magnetic field of the MRI scanner. T2* is field strength dependent.

 

What does T2* measure?

In the liver, iron deposits (typically in the form of ferritin and hemosiderin) cause magnetic field inhomogeneities and have a measurable effect on T2*. Tissues with high iron typically have very low T2*, while tissues with low iron have higher T2* values (see Figure 1). The relationship between T2* and liver iron concentration (mg/g dry weight of tissue) has been well validated using empirically derived relationships between biopsy and MRI measurements.19

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How T2* may appear on a report

Standardization of cT1
Standardization of LiverMultiScan IDEAL PDFF